The correct answer is C. Alpha-latrotoxin.
The black widow spider bite manifests as an acutely painful bite without necrosis. The effects are mediated by alpha-latrotoxin. Histamine is found in the venom of the wolf spider. Sphingomyelinase D is found in the venom of the brown recluse. Hyaluronidase is found in the venom of the jumping spider. Lipase is found in the venom of the sac spider.