Pop Quiz #142

The correct answer is C. Anti-Mi-2.

This patient has dermatomyositis. Anti-Mi-2 antibodies in DM correlate with the presence of a shawl sign, cuticular changes, and good prognosis.

Anti-Jo-1 antibodies correlate with pulmonary fibrosis, Raynaud’s, and polyarthritis. Anti-SRP antibodies correlate with cardiac disease and poor prognosis. Anti-Ku antibodies correlate with sclerodermatomyositis. Anti-La antibodies correlate with Sjogren’s syndrome.


Matsuda T, et al. Four cases of anti-Mi-2 antibody-positive dermatomyositis: relationship between anti-Mi-2 antibody titre and disease severity and activity. J Eur Acad Dermatol Venereol. 2018 Jun;32(6):e233-e234. [https://www.ncbi.nlm.nih.gov/pubmed/29237096]