The correct answer is C. IL-36.
IL-36. Spesolimab is a novel, selective humanized anti–interleukin-36 receptor monoclonal antibody recently approved by the for the treatment of adults with GPP.1
IL-17 inhibitors approved for plaque psoriasis include secukinumab, ixekizumab, and brodalumab. Bimekizumab is also an IL-17 inhibitor in ongoing clinical trials for plaque psoriasis. IL-23 inhibitors approved for plaque psoriasis include guselkumab, risankizumab, ustekinumab, and tildrakizumab.2 None of these are specifically approved for plaque psoriasis. Tralokinumab is an IL-13 blocker FDA approved for atopic dermatitis. Lebrikizumab is another fully humanized anti-IL-13 antibody that does not block the binding of the cytokine to the receptor but instead impairs the heterodimerization of IL-4Rα and IL-13Rα1, thereby inhibiting signal transduction, but is still in clinical trials.3 Nemolizumab is not currently FDA approved in the United States but is a subcutaneously administered humanized anti-interleukin-31 (IL-31) receptor A (IL-31RA) monoclonal antibody that is being developed for the treatment of skin diseases, including atopic dermatitis (AD), AD associated pruritus, prurigo nodularis, chronic kidney disease associated pruritus, and systemic sclerosis.4
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