ANSWER: Oculocutaneous Albinism Test Question

The correct answer is B. P gene

Correct Answer Explanation

OCA type 2 (tyrosinase positive albinism) is caused by mutations in the P gene, which encodes a pH-regulating protein to support melanogenesis.

Incorrect Answer Explanation

Oculocutaneous albinism (OCA) type 1 (Tyrosinase negative albinism) is caused by mutations in the tyrosinase gene. OCA type 3 is caused by mutations in the tyrosinase related protein 1 gene. C-kit mutations cause piebaldism and NEMO mutations cause incontinentia pigmenti.

References

The pink-eyed dilution gene and the molecular pathogenesis of tyrosinase-positive albinism (OCA2). Manga P, Orlow SJ. J Dermatol. 1999 Nov;26(11):738-47.