Friday Pop Quiz #4 – 1/25

Basal Cell Carcinoma

Correct Answer: E

Explanation: Imiquimod is a topical immunomodulator that is FDA-approved for the treatment of genital warts, actinic keratosis and superficial basal cell carcinomas. It induces toll like receptor (TLR) 7 and the production of Th-1 cytokines including tumor necrosis factor (TNF)-α , interferon (IFN)-γ , interferon (IFN)-α , and interleukin (IL)-12, leading to stimulation of a cell-mediated immune response. IL-4, IL-5, IL-6 and IL-13 are Th-2 cytokines.

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Reference: Stanley MA. Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential. Clin Exp Dermatol 2002; 27(7): 571-577.

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