Explanation: Bullous pemphigoid is the most common immunobullous disorder and presents with tense vesicles and bullae and pruritus. Autoantibodies are directed against the NC16A domain of BPAg2 also known as BP180 or collagen XVII.
Reference: Matsumura K, Amagai M, Nishikawa T, et al. The majority of bullous pemphigoid and herpes gestationis serum samples react with the NC16a domain of the 180-kDa bullous pemphigoid antigen. Arch Dermatol Res. 1996;288:507-09.
Don’t Agree? Tell us why in the comments section below.