Refractory Alopecia Areata and Vitiligo Responding to Tofacitinib Monotherapy
Tofacitinib
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INTRODUCTION Tofacitinib is a Janus kinase (JAK) 1-3 inhibitor first U.S. Food and Drug Administration (FDA) approved in 2012 for rheumatoid arthritis, with subsequent approval for psoriatic arthritis, ulcerative colitis, polyarticular course juvenile idiopathic arthritis, and ankylosing spondylitis in 2017, 2018, 2020, and 2021, respectively.1,2¬†In the last several years, oral tofacitinib …
Severe Psoriasis Presenting in 3-Year-Old Child With Nail Dystrophy: Response to Biologic Treatment
psoriasis
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Psoriasis, a chronic inflammatory skin condition, affects about 2% of children. A small subset have isolated nail involvement refractory to topical treatment that can be disabling. The development of targeted biologic agents offers safe, effective options for children with moderate-to-severe skin and nail disease. A few are now Food and Drug Administration (FDA)-approved for children. INTRODUCTIO …
Pediatric Verrucous Psoriasis: A Case Report in a Pediatric Patient
Pediatric Verrucous Psoriasis
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Verrucous psoriasis (VP) is a rare histologic variant of psoriasis. To date, fewer than 40 cases have been reported, with pediatric cases representing an exceedingly small fraction. Treatment options are limited, and the disease is often refractory to conventional methods. Herein, JDD authors Samantha Sherkin OMS-IV, Christian Summa OMS-IV, David Crasto DO, Zackary Whitney DO, Lazlo Karai MD PhD,¬ …
PRP for Scarring Alopecia Due to Discoid Lupus Erythematosus (DLE)
PRP
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JDD authors Hannah Polster MD, Karen Kagha MD, and ¬†Janiene Luke MD report a case of platelet rich plasma for the treatment of scarring alopecia due to discoid lupus erythematosus. Platelet-rich plasma (PRP) is an autologous concentration of plasma from a patient's blood containing platelets up to 7 times higher than normal plasma.1 Originally indicated to improve connective tissue regeneratio …
Successful Treatment of Cheilitis Granulomatosa With Certolizumab and Ustekinumab
Cheilitis Granulomatos
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INTRODUCTION Cheilitis granulomatosa (CG) is a subtype of orofacial granulomatosis that results in facial and oral swelling in the absence of non-caseating granulomatous systemic diseases such as Crohn‚Äôs and sarcoidosis.1¬†With concurrent facial palsy and a plicated tongue, the condition is referred to as Melkersson-Rosenthal syndrome.1,2¬†Both CG and Melkersson-Rosenthal syndrome are in the …