Topical Ketoconazole Therapeutic Cheat Sheet
Topical KetoconazoleKetoconazole is an imidazole antifungal that was initially FDA-approved in an oral formulation for the treatment of systemic fungal infections. While oral ketoconazole has largely fallen out of use due to safety concerns, including hepatotoxicity, endocrine dysregulation, and drug interactions, topical ketoconazole has proven to be a safe and effective treatment for superficial fungal infections. …
Topical Ketoconazole
Calcipotriene Therapeutic Cheat Sheet
CalcipotrieneCalcipotriene is a synthetic Vitamin D3 analogue with various functions, including promoting cellular differentiation and reducing inflammatory cytokines. The unique mechanism of action of calcipotriene has expanded its utility beyond psoriasis to off-label uses for other dermatologic conditions. Calcipotriene is well tolerated and can be used in conjunction with other treatment modalities. We con …
Calcipotriene
Pentoxifylline Therapeutic Cheat Sheet
PentoxifyllinePentoxifylline is a methyl-xanthine derivative traditionally used to treat symptoms of peripheral vascular disease and has emerged as a valuable therapeutic agent in dermatology for its anti-inflammatory and immunomodulatory properties. We continue our series, Therapeutic Cheat Sheet, with a closer look at pentoxifylline, which is FDA-approved for the treatment of intermittent claudication and is …
Pentoxifylline
Ritlecitinib Therapeutic Cheat Sheet
RitlecitinibAlopecia areata (AA) is a nonscarring alopecia driven by autoreactive cytotoxic CD8 T cells against hair follicle antigens. With an unpredictable clinical course, which can include alopecia totalis and universalis, AA can be debilitating to patients’ quality of life. Historically, glucocorticosteroids, cyclosporine, methotrexate, and azathioprine were used off-label for non-targeted immunosuppre …
Ritlecitinib
Patient Buzz: The Staph-Itch Connection | The Expert Weighs In
itchHealthCentral recently highlighted new research out of Harvard Medical School on the role of Staphylococcus aureus (S. aureus) in itch. Researchers found S. aureus can trigger itch in mice and human cells through communication with sensory neurons. For an expert’s take, I reached out to Gil Yosipovitch, MD, professor, Stiefel Chair of Medical Dermatology and director of the Miami Itch Center …
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