The correct answer is C. Interleukin-13.

IL-13 is an important T-helper cell 2 cytokine involved in acute inflammation of
atopic dermatitis.

While interferon-gamma, interleukin-2, transforming growth factor-beta, and
tumor necrosis factor-alpha may be involved in an inflammatory response, they are not most implicated in acute inflammation of atopic dermatitis.

References:

Wollenberg A, Howell MD, Guttman-Yassky E, et al. Treatment of atopic
dermatitis with tralokinumab, an anti-IL-13 mAb. J Allergy Clin Immunol.
2019;143(1):135-141.