The correct answer is C. Peutz-Jeghers syndrome.

Peutz-Jeghers syndrome results from an autosomal-dominant mutation in the STK11 gene (serine threonine kinase). Clinical manifestations may include: mucocutaneous (oral/acral) lentigines, intestinal polyposis +/- intussusception, and various malignancies.

The remaining answer choices may produce multiple lentigines, but are not typically associated with intussusception.

References:

PMID: 20581245