The correct answer is D. Prednisone.

The clinical presentation most likely represents Sweet syndrome (acute febrile neutrophilic dermatosis). Classical Sweet syndrome is frequently associated with recent infections, IBD and pregnancy. Diagnosis is made with 2 major and 2 minor criteria. Major criteria: 1. Abrupt onset of painful erythematous plaques 2. Histopathological evidence of a dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis Minor criteria: 1. Fever 2. Association with malignancy, inflammatory disease, pregnancy or recent URI, GI infection, vaccination 3. Excellent response to systemic steroids 4. Abnormal lab values (ESR, CRP, leukocytosis, >70% neutrophils).

The other answer choices are not the first-line treatment of Sweet syndrome.

References:

Nelson CA, Stephen S, Ashchyan HJ, et al. Neutrophilic dermatoses: Pathogenesis, Sweet syndrome, neutrophilic eccrine hidradenitis, and Behçet disease. J Am Acad Dermatol. 2018 Dec;79(6):987-1006. [https://www.ncbi.nlm.nih.gov/pubmed/29653210]

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