Friday Pop Quiz 3/20/2026
What histologic features are typically seen on a skin biopsy of this lesion?
A. Necrobiotic degeneration of dermal collagen surrounded by an inflammatory reaction
B. Layers with open-ended necrobiotic foci; lack of mucin; increased numbers of plasma cells (necrobiosis lipoidica)
C. Larger areas of eosinophilic necrobiosis and a lack of mucin deposition (rheumatoid nodule)
D. Immuno …
What histologic features are typically seen on a skin biopsy of this lesion?
A. Necrobiotic degeneration of dermal collagen surrounded by an inflammatory reaction
B. Layers with open-ended necrobiotic foci; lack of mucin; increased numbers of plasma cells (necrobiosis lipoidica)
C. Larger areas of eosinophilic necrobiosis and a lack of mucin deposition (rheumatoid nodule)
D. Immuno … 
A 75-year-old man presents with tense bullae as pictured. DIF reveals linear IgG and C3 at the dermal-epidermal junction. On salt-split skin, immunoreactants are localized to the roof of the specimen. What is the target antigen?
A. Type VII Collagen
B. Type XVII collagen (BP180)
C. Laminin 332
D. Desmoglein 1
E. Integrin α6β4
To find out the correct answer and read the expl … 
A 55-year-old female presents with concerns about plaques on both of her eyelids. Which of the following statements is true regarding this patient's skin condition?
A. These are the least common type of xanthoma
B. Most commonly associated with hyperglycemia
C. Lesions arise asymmetrically
D. Lesions start off as many bumps that grow rapidly
E. Lesions are soft, velvety, yellowi … 
What is the most common site of extracutaneous involvement in this non-infectious disease?
A. Lungs
B. Eyes
C. Bone Marrow
D. Liver
E. Nasal mucosa
To find out the correct answer and read the explanation, click here.
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Which ocular finding may be seen in a patient with this skin condition?
A. Comma-shaped corneal opacities
B. Retinitis pigmentosa
C. Congenital hypertrophy of the retinal pigmented epithelium
D. Angioid streaks
E. Pingueculae
To find out the correct answer and read the explanation, click here.
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