Friday Pop Quiz 1/23/2026
A 35 year old man presents with this lesion shown in the photo on his hand. The patient undergoes a biopsy for confirmation of the diagnosis. What finding is specific for this condition?
A. Wedge-shaped perivascular lymphocytic infiltrate with eosinophils
B. Fibrinoid necrosis and leukocytoclasia
C. Collapsed keratin bundles
D. Peforating elastin, parakeratosis
E. Epithelial cel …
A 35 year old man presents with this lesion shown in the photo on his hand. The patient undergoes a biopsy for confirmation of the diagnosis. What finding is specific for this condition?
A. Wedge-shaped perivascular lymphocytic infiltrate with eosinophils
B. Fibrinoid necrosis and leukocytoclasia
C. Collapsed keratin bundles
D. Peforating elastin, parakeratosis
E. Epithelial cel … 
Mutations in which gene would likely be found in the neoplastic cells of this lesion?
A. PATCH
B. p53
C. Fumarate hydratase
D. CREBBP
E. p63
To find out the correct answer and read the explanation, click here.
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What is the most likely diagnosis based on the following dermoscopic photograph of this asymptomatic lesion?
A. Squamous cell carcinoma
B. Angioma
C. Clear cell acanthoma
D. Basal cell carcinoma
E. Psoriasis
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This patient should be treated with what medication to avoid further scarring?
A. Topical tretinoin
B. Minocycline
C. Isotretinoin
D. Spironolactone
E. Bactrim
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Image creadi … 
What is the underlying gene defect for this transgrediens form of palmoplanter keratoderma?
A. SLURP-1
B. TOC gene
C. Plakoglobin
D. Keratin type 1
E. Keratin type 9
To find out the correct answer and read the explanation, click here.
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