Alitretinoin Therapeutic Cheat Sheet
alitretinoinAlitretinoin (9-cis-retinoic acid) is a naturally occurring endogenous retinoid that in gel form is FDA approved for AIDs-related localized cutaneous Kaposi’s sarcoma (KS)1. As compared to other topical retinoids, alitretinoin is unique in that it binds to all known intracellular retinoid receptors (RARs and RXRs), allowing it to exert anti-proliferative and apoptotic effects, particularly usefu …
alitretinoin
Friday Pop Quiz #250
The correct answer is B. Atopic dermatitis. The hypopigmented patches and thin plaques on the face of this child are most consistent with a diagnosis of pityriasis alba, which is most strongly associated with atopic dermatitis. Autoimmune conditions, like vitiligo, may be associated with alopecia areata, but these resulted in depigmented patches. Neurofibromatosis I and Tuberous sclero …
Friday Pop Quiz #248
The correct answer is D. Interleukin-31.  Recognize the pruritic plaques, which are now lichenified, as a common presentation of atopic dermatitis. Pruritogenic interleukin-31 is, of the options shown, most responsible for the pruritus in this condition. Defensins—a type of antimicrobial peptides—are decreased in atopic dermatitis, thus making patients at an increased risk for inf …
Friday Pop Quiz #247
The correct answer is E. Pregnancy. This is a pyogenic granuloma. In pregnancy, the lesion occurs most frequently over the buccal mucosa and gingivae. Pyogenic granulomas commonly appear within the nail apparatus, where they may be periungual or subungual, and often follow penetrating trauma. Other common causes of pyogenic granuloma of the nail include ingrown toenails, systemic drugs ( …
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