Topical PDT Photosensitizers (5-ALA and MAL) Therapeutic Cheat Sheet
5-aminolevulinic acid (5-ALA) is an FDA-approved prodrug used in combination with light therapy for treatment of actinic keratosis and superficial basal cell carcinoma. It is a naturally occurring amino acid that is an intermediate of the heme biosynthesis pathway which cells convert into the photosensitizing metabolite protoporphyrin IX (PpIX). This compound has been applicable in two specific cl …
5-aminolevulinic acid (5-ALA) is an FDA-approved prodrug used in combination with light therapy for treatment of actinic keratosis and superficial basal cell carcinoma. It is a naturally occurring amino acid that is an intermediate of the heme biosynthesis pathway which cells convert into the photosensitizing metabolite protoporphyrin IX (PpIX). This compound has been applicable in two specific cl … Continue reading "Topical PDT Photosensitizers (5-ALA and MAL) Therapeutic Cheat Sheet"
Surgery is the gold standard for skin cancer treatment, but sometimes surgery isn’t the best option. Perhaps the patient isn’t healthy enough or the patient simply refuses to go under the knife. Topical therapy is an alternative, but patient compliance is a concern. Enter fractional laser-assisted drug delivery (LADD): a non-surgical approach that enhances penetration of topical treatments, le … 
Following up on insights shared at the ODAC Dermatology Conference, Dr. Neal Bhatia, MD, FAAD, Director of Clinical Dermatology at Therapeutics Clinical Research, offered a comprehensive overview of actinic keratosis (AK) management. Dr. Bhatia emphasized actionable approaches to balancing prescription topicals and procedural techniques in everyday practice.
The incidence for non-melanoma skin … 
The February issue of the Journal of Drugs in Dermatology (JDD) includes the perfect blend of original articles, case reports, and brief communications exploring topics such as efficacy and safety of 1% clascoterone cream in patients aged ≥12 years with acne vulgaris, dupilumab’s impact on atopic dermatitis among adolescent and adult patients, development and validation of a photonumeric scale … 
The August issue of the Journal of Drugs in Dermatology (JDD) focuses on Psoriasis and features mix of original articles, editorials, and case reports. Among many of the topics explored in this issue are treatment of scalp psoriasis, nail psoriasis, respiratory tract infections in patients using biologics for hidradenitis suppurativa, classification of actinic keratosis, lichen planus pigmentosus …