Friday Pop Quiz 3/13/2026
A 75-year-old man presents with tense bullae as pictured. DIF reveals linear IgG and C3 at the dermal-epidermal junction. On salt-split skin, immunoreactants are localized to the roof of the specimen. What is the target antigen?
A. Type VII Collagen
B. Type XVII collagen (BP180)
C. Laminin 332
D. Desmoglein 1
E. Integrin α6β4
To find out the correct answer and read the expl …
A 75-year-old man presents with tense bullae as pictured. DIF reveals linear IgG and C3 at the dermal-epidermal junction. On salt-split skin, immunoreactants are localized to the roof of the specimen. What is the target antigen?
A. Type VII Collagen
B. Type XVII collagen (BP180)
C. Laminin 332
D. Desmoglein 1
E. Integrin α6β4
To find out the correct answer and read the expl … 
Our new series, “The Many Faces of”, showcases side-by-side images of some of the most commonly seen dermatology conditions in an array of skin tones and briefly highlight nuances in clinical presentation. All images featured in the series are part of The Full Spectrum of Dermatology: A Diverse and Inclusive Atlas, a resource developed by co-editors Misty Eleryan, MD, MS, and Adam Friedman, … 
A 65-year-old female patient presents with poorly demarcated, symmetric, very painful patches of erythema and retiform purpura, favoring the thighs and buttocks. Bullae and a dusky gray discoloration developed, as well as the appearance of ulcerations with black, leathery eschars. A skin biopsy of the affected area is suggestive of calciphylaxis. Shortly after, she dies from secondary infectio …