No Brainer Approaches to Neutrophilic Dermatoses
At the 2025 ODAC Dermatology conference, Dr. Anthony Fernandez, MD, PhD gave an informative presentation titled, No-Brainer Approaches to Neutrophilic Dermatoses. His presentation focused on discussing the clinical presentation, differential diagnosis considerations, and treatment options of pyoderma gangrenosum and Sweet syndrome.
Pyoderma Gangrenosum (PG)
Pyoderma gangrenosum typically present …
At the 2025 ODAC Dermatology conference, Dr. Anthony Fernandez, MD, PhD gave an informative presentation titled, No-Brainer Approaches to Neutrophilic Dermatoses. His presentation focused on discussing the clinical presentation, differential diagnosis considerations, and treatment options of pyoderma gangrenosum and Sweet syndrome.
Pyoderma Gangrenosum (PG)
Pyoderma gangrenosum typically present … Continue reading "No Brainer Approaches to Neutrophilic Dermatoses"
This 48 year old woman tells you these lesions began as "acne bumps" on her legs. A biopsy reveals ulceration and a mixed inflammatory infiltrate, including neutrophils. A tissue culture for infectious organisms is negative. What is the most likely underlying systemic condition in this patient?
A. Celiac disease
B. Ovarian cancer
C. Chronic pancreatitis
D. IgA monoclonal gammopathy … 
Generalized pustular psoriasis (GPP) is a rare, autoinflammatory condition, with acute, severe flares of diffuse sterile pustules and systemic symptoms that can be life-threatening. Historically, cyclosporine, methotrexate, retinoids, and biologics modulating the interleukin-17 (IL-17), IL-23, and tumor necrosis factor α pathways have been used off-label for management.1 Aberrant IL-36 signaling … 
2021 is the 50th anniversary of the FDA approval of minocycline (MCN). While many other antibiotics have become obsolete during this time, MCN continues to be quite useful. In dermatology, MCN is used prominently in acne vulgaris, and is also employed in many other dermatological conditions because of its molecular and pharmacological properties. In this article, we review the history of minocycli … 
On this Mnemonic Monday, we challenge you to remember diseases that are associated with IgA monoclonal gammopathies. Remember that IgA related diseases are typically neutrophil predominant.
Mnemonic:
SWEET PEPSI
Sweet's Syndrome
Pyoderma Gangrenosum
Erythema Elevatum Diutinum (EED)
POEMS
Subcorneal Pustular Dermatosis
IgA pemphigus
Click HERE to download or print your mnemonic c … 