rash

Utility of Pulsed-Dye Laser in the Treatment of Recalcitrant Hailey-Hailey Disease
Hailey-Hailey Disease INTRODUCTION Benign Familial Pemphigus, or Hailey-Hailey Disease (HHD), affects intertriginous areas of the skin causing epidermal blistering and vesicles that coalesce into weeping and crusting plaques.¹ The loss-of-function mutation of the ATP2C1 gene causes a disruption in calcium homeostasis of keratinocytes. The resulting dysfunction in desmosomes and cell-cell adhesion causes acanthol …
Hailey-Hailey Disease
Skin Pustules – Friday Pop Quiz 1/20/2023
A patient comes in with the rash pictured below consisting of pustules in an annular or polycyclic configuration. What type of paraproteinemia can this disorder be associated with and thus a workup should be initiated for? A. IgG kappa B. IgG lambda C. IgA D. IgM E. IgD To find out the correct answer and read the explanation, click here.    Brought to you by our brand …
Sudden Onset Rash – Friday Pop Quiz 1/21/2022
A 14-year-old female presents with the sudden onset of the skin findings pictured diffusely covering greater than 90% of her skin surface. The rash is accompanied by a high fever (40C) and elevated white blood cell count. What is the most likely cause of her condition? A. ABCC6 mutation B. Anti-FceR1 IgG antibodies C. Anti-transglutaminase 3 antibodies D. Deficiency of the IL-36 re …
Histocompatibility Antigen – Friday Pop Quiz 1/14
A 23-year-old female presents with itchy and irritated rash in the image. The rash began in her late teens. She has a family history of similar rash in her mother. Which histocompatibility antigen is most likely in this patient? A. HLA-Cw2 B. HLA-Cw6 C. HLA-B51 D. HLA-B27 E. HLA-Bw35 To find out the correct answer and read the explanation, click here.    Brought to yo …
Sneaky Cases of Allergic Contact Dermatitis
allergic contact dermatitisWe all think about allergic contact dermatitis when a patient presents with a classic well-demarcated distribution of eczematous, pruritic rash. But under what other clinical scenarios should we consider the diagnosis of allergic contact dermatitis? At the 17th Annual ODAC Dermatology, Aesthetic and Surgical Conference, Dr. Jonathan Zippin discussed three different clinical conundrums that should …
allergic contact dermatitis