Pruritic Rash – Friday Pop Quiz 6/4
This healthy 2-year-old female presents with a 2-day history of the pruritic rash seen here. She had mild edema of the dorsal hands and feet and positive dermatographism on exam. All lesions were transient, lasting less than 24 hours in the same location. She was otherwise well and her parents denied any fever or systemic symptoms. What is the best diagnosis?
A. Serum sickness-like reaction …
This healthy 2-year-old female presents with a 2-day history of the pruritic rash seen here. She had mild edema of the dorsal hands and feet and positive dermatographism on exam. All lesions were transient, lasting less than 24 hours in the same location. She was otherwise well and her parents denied any fever or systemic symptoms. What is the best diagnosis?
A. Serum sickness-like reaction … 
Pruritus, whether related to inflammatory skin conditions or systemic disease, can be debilitating for patients. In order to improve quality of life for patients suffering from severe pruritus, dermatologists often resort to off-label use of systemic medications. In this month’s installment of our Therapeutic Cheat Sheet Series, we will discuss use of naltrexone for treatment of pruritus.
Naltr … 
Skin of color is often interpreted simply as “non white” when in fact it should be viewed as a variety of hues on a spectrum. It is important for dermatologists to be equipped with the necessary skills to treat an array of skin tones because one finite mistake can cause unfavorable results depending on the amount of pigment in a patient’s skin. I had the pleasure of interviewing Dr. Marjon V … 
A 6-month old infant develops tense blisters on the distal extremities which develop on normal-appearing skin. He has a neurologic disease and has been immobilized for a long period of time. The blisters spontaneously heal within 1-2 weeks. You suspect a diagnosis of coma bullae. Which of the following is the key characteristic histologic feature that would assist you in making this diagnosis? … 
Just as pigmented lesions on the skin can vary widely from freckles to lentigines to nevi to melanoma, similar pigmented lesions can be seen in nails. Melanonychia, brown or black pigmentation in the nail plate, can frequently present a diagnostic challenge for the dermatologist. While most causes of melanonychia are benign, it is important to recognize when the diagnosis is malignant or uncerta … 