On this Mnemonic Monday, we challenge you to remember immunohistochemical markers for paget cells in Extramammary Paget’s Disease with the following mnemonic:
Extra– Extramammary Paget’s Disease
Gross– Gross cystic disease fluid protein 15 (GCDFP-15)
LOVE- Low molecular weight cytokeratins
PASses- Period acid-Schiff (PAS)
CANCER- CEA
The word cancer also helps you remember that you are referring to Extramammary Paget’s
Click HERE to download or print your mnemonic card.
Study More!
Need a refresher on Extramammary Paget’s Disease ? Check out page 306 of your 2020 Derm In-Review Study Guide.
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Further Reading
Check out the following case report published in the Journal of Drugs in Dermatology (JDD):
Bilateral Contiguous Scrotal Extramammary Paget’s Disease Treated With Mohs Micrographic Surgery and CK7 Immunohistochemical Staining
Extramammary Paget’s Disease (EMPD) is a rare malignancy that commonly presents on apocrine-rich skin as a unilateral scaly patch or plaque that often grows slowly and asymmetrically. There is growing evidence to suggest that Mohs micrographic surgery may provide better patient outcomes and lower recurrence rates compared to wide local excision. We present a rare case of Extramammary Paget’s Disease presenting as bilateral scrotal patches that were found via cytokeratin-7 (CK7) staining during Mohs micrographic surgery to connect subclinically in a contiguous fashion around the base of the penis. Read the full article here.
Test your knowledge!
Which of the 
following statements is TRUE regarding this lesion?
A: Is due to a mutation in PTCH
B: Most commonly presents on genitalia
C: Stains negative for CK20 if associated with underlying GI/GU malignancy
D: Arises from eccrine gland
E: Surgical excision/Mohs is not helpful
To find out the correct answer and read the explanation, click here.
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