It’s Mnemonic Monday! Mast Cell Degranulators

On this Mnemonic Monday, we challenge you to remember mast cell degranulators (patients should avoid these triggers in mastocytosis and urticaria pigmentosa) with the following mnemonic:


SPSubstance P, polyxin

IIgE (dimerized)


EE for Epsilon (E),  anti-FcεRI antibody

SStem cell factor (Kit ligand)




I– reminder for IgE and FcεRI antibody



Click HERE to download or print your mnemonic card.

Study More!

Need a refresher on mast cells? Check out page 24 of your 2020 Derm In-Review Study Guide.

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Further Reading

Check out the following JDD article on today’s topic:

A Review of the Dermatologic Symptoms of Idiopathic Mast Cell Activation Syndrome

Since the first reported cases in 2007, idiopathic mast cell activation syndrome has been increasingly recognized. Understanding of the cutaneous manifestations of this condition is imperative for dermatologists given the substantial clinical heterogeneity in its presentation and high estimated prevalence. A review of PubMed® and SCOPUS® databases was performed in order to investigate the most common dermatologic manifestations of idiopathic mast cell activation syndrome. Evidence to date suggests that flushing, pruritus, and clotting dysfunction or bleeding disorder are the most frequently observed dermatologic symptoms in idiopathic mast cell activation syndrome, while dermatographism has been identified as a common finding in patients as well. Mast cell activation syndromes have also been linked to connective tissue disorders, including an Ehlers-Danlos Syndrome-like phenotype possibly mediated by matrix metalloproteinases and tryptase released by mast cells. Current literature regarding dermatologic manifestations of idiopathic mast cell activation syndrome is limited by the heterogeneity of studies including clinical descriptions, inconsistency of diagnostic criteria implemented, and a paucity of literature available. This work provides a guide for dermatologists to strengthen diagnostic acuity for idiopathic mast cell activation syndrome, therefore contributing toward a goal of helping patients to receive timely, effective, and targeted therapy. Read the full article here.

J Drugs Dermatol. 2019;18(2):162-168.

Test your knowledge!

A 4 month-old with diffuse blisters and erosions has a skin biopsy diagnostic of generalized mastocytosis. Which topical agent should be avoided in this patient?

A. Mupirocin ointment

B. Polymyxin B ointment

C. Petrolatum

D. Clobetasol ointment

E. Silver sulfadiazine

To find out the correct answer and read the explanation, click here.

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