Up and Close with Dr. Perez – A Fascinating New Study on the Aging Process Across Ethnic Variations

There are clearly differences in the aging process among various ethnic skin types but until now, we have only had an overall idea that these disparities exist. Now, for the first time, results of a scientific evaluation underwritten by Procter & Gamble Co. show that these phenotypic differences actually have a pathophysiologic and histologic basis. Dr. George Han had the pleasure of interviewing Dr. Perez, who serves as a Scientific Advisor to Procter & Gamble Co., about this intriguing work and how it can guide our approach to photoaging in different skin types.

Dr. Han: Please tell us a bit about the project you’re working on

Dr. Perez: We looked at clinical, histologic, and molecular changes in photoexposed and photoprotected skin among several hundred women of different ethnic origins, from a wide range of ages. This is a multicenter, multipart study where we used specific genetic profiles to determine ethnic origin (Caucasian/Northern European, African, Hispanic, and Chinese) and compared differences among groups. We used transcriptomics profiling as well as histologic examination from biopsy samples in both photoexposed (face/scalp and dorsal forearm) and photoprotected (buttocks) skin.

Dr. Han: Can you tell me about the first study that was published in this series?

Dr. Perez: The first paper published from this series is interesting in that instead of looking at different ethnic groups, they looked at Caucasians among different decades and compared markers of the aging process with groups identified as “fast-agers” or “slow-agers.” In this study, “younger-looking” skin vs. “older-looking” skin was determined via a crowdsourcing methodology to obtain a clinical baseline and an “appearance age” score. There were significant differences with younger- or older-appearing skin with regards to genetic pathways involved in oxidative stress, energy metabolism, senescence, and epidermal barrier.

Dr. Han: What are the basic parameters studied?

Dr. Perez: Pathology was first evaluated for elastosis (% elastosis) via H&E stained skin sections. Laser confocal microscopy was used to isolate the skin into epidermis and dermis (with adnexal structures and subcutaneous adipose tissue removed) for transcriptome analysis while mRNA analysis was performed on full-thickness samples.

Genetic ancestry was determined via a custom analysis from 23andMe.

Dr. Han: What are some big-picture differences among ethnic groups that you can share with us?

Dr. Perez: The main question that we are trying to address is, are there any major differences in the aging process among African Americans, Caucasians, and other ethnic groups? There are a lot of assumptions out there that there are differences but there have been no formal studies to confirm this, so that’s what we sought to change here. Via genetic analysis, we can precisely determine one’s genetic origins and can scientifically prove differences between these groups with regards to photoaging.

Starting in the fourth decade in Caucasians, you start seeing elastosis in sun-exposed areas which becomes very marked in the sixth decade. In African Americans, there is no elastosis whatsoever. Compared to Hispanics, elastosis starts more in the sixth decade and you don’t see much in the fourth decade. For the Chinese population, elastosis was comparable to Hispanic skin; there is considerable elastosis in the sixth decade, but not the fourth decade either.

Expression of proteins involved in the aging process for the fifth decade of Caucasians is equivalent to that of the sixth decade in African Americans. The protein and gene expression of factors involved in the aging process is therefore delayed by an entire decade in African Americans.

Dr. Han: How can this help us in our approach to patients?

Dr. Perez: Our clinical approach to aging revolves around preventative and treatment modalities. Knowing that the aging process is qualitatively and quantitatively different will help guide our treatment approach, guiding us towards specific interventions targeted towards different problems such as loss of volume, wrinkles, or discoloration. What I want to make sure people don’t take from this work is to have a feeling that African Americans can be cavalier about sun protection; everyone should use plenty of sunblock and engage in safe skin protection practices, no matter what ethnic or genetic origin!

Dr. Han: What are the implications of this study for future work?

Dr. Perez: Theoretically, this study can help us address the aging process among different ethnicities because they are fundamentally different. If we can isolate specific proteins that are differentially expressed among these various ethnic groups, we can design an intervention to attack these specific proteins, proteases, and other factors that affect collagen, elastin, and hyaluronic acid, which affect appearance of aging. Another interesting factor to study going forward relates to the microbiome; how does the microbiome change with different decades among different ethnicities, and how does that relate to the aging process?

Disclosures: Dr. Maritza Perez is a Cutera speaker, Procter & Gamble Co. Scientific Advisor, and a consultant for La Roche-Posay

To read more about the study “Age-induced and photoinduced changes in gene expression profiles in facial skin of Caucasian females across 6 decades of age”, click here.

About Maritza I. Perez, MD

Perez
Maritza Perez, MD

Dr. Perez is certified by the American Board of Dermatology and the College of Mohs Micrographic Surgery and is the Director of Cosmetic Dermatology at Mount Sinai West Medical Center in New York. She is Clinical Professor of Dermatology at Mount Sinai Icahn School of Medicine. Her dermatology private practice, Advanced Aesthetics, is located in New Canaan, CT. Dr. Perez specializes in Mohs micrographic, laser, and cosmetic SurgeryDr. Perez is an active member in numerous dermatology organizations, such as the American Society for Dermatologic Surgery, American Women Society for Dermatologic Surgery, American Society for Laser in Surgery and Medicine, American Academy Dermatology Women Association, Dermatology Foundation, and is Senior Vice President for the Skin Cancer Foundation.

Dr. Perez has published over 100 original articles, chapters, case reports and abstracts that have appeared in many prestigious medical journals, and authored a book titled Understanding Melanoma which is on its fifth edition. In addition, Dr. Perez has spoken at a number of dermatology engagements both nationally and internationally. Dr. Perez has served as scientific advisor and consultant for some cosmetics and laser companies including Procter & Gamble Co., L’Oreal and Cutera. Dr. Perez has been recognized as one of the best Dermatologist and Cosmetic Dermatologists in the years 1999-2005. Recently, January 17, 2014, received The Leaders of Distinction Awards in the field of Aesthetics given by the Journal of Drugs in Dermatology peered group selection. For the past three years, she had received Excellence in Cosmetic training and teaching award from the dermatology residents at Mount Sinai.

Dr. Perez is a graduate of the University of Puerto Rico, School of Medicine where she also completed her residency in dermatology. In addition, she completed post-doctoral training in Immunodermatology at Columbia College of Physicians and Surgeons in New York, NY and Dermatologic Surgery including Mohs Micrographic and Laser Surgery and Cosmetic Dermatologic Surgery at New York University.

 

About George Han, MD

George Han, MD

Dr. George Han currently serves as the Chairman of the Department of Dermatology at Mount Sinai Beth Israel. He is also the Director of Teledermatology for the Department of Dermatology at the Icahn School of Medicine at Mount Sinai.
Following graduation from the University of Southern California, where Dr. Han received his B.S. in Biomedical Engineering cum laude, he entered the MD, PhD Medical Scientist Training Program in the Department of Physiology and Biophysics at Albert Einstein College of Medicine successfully completing the program in 2011. He completed a preliminary year in Internal Medicine at the Mount Sinai School of Medicine prior to entering the Dermatology residency program at Albert Einstein College of Medicine’s Montefiore Medical Center, where he served as Chief Resident during his final year. Dr. Han is Board Certified in Dermatology and is licensed to practice medicine in New York.

Dr. Han is the recipient of numerous awards including a Science and Travel Award for Outstanding Research to attend the 3rd International Meeting on the Role of Nitrite in Physiology, Pathophysiology, and Therapeutics in Sweden (2009), DermMentors Resident of Distinction Award, First Prize in the Resident’ Competition (2013), and a co-winner of the Everett C. Fox Award in the Residents and Fellows Symposium at the 2014 Annual Meeting of the American Academy of Dermatology. He is also the recipient of a Women’s Dermatologic Society grant for his research. The Journal of Drugs in Dermatology Leaders of Distinction program also recognized Dr. Han with a Resident of the Year Award (2015) during his training.