Pop Quiz #153
The correct answer is D. Deficiency of the IL-36 receptor antagonist.
The patient presents with generalized pustular psoriasis (GPP) secondary to deficiency of the IL-36 receptor antagonist (DITRA). IL-36R antagonist is in the IL-1 family and antagonizes proinflammatory IL-36. DITRA has been shown to cause familial and sporadic GPP as well as localized acrodermatitis continua of Hallopeau. …