methotrexate

Refractory Alopecia Areata and Vitiligo Responding to Tofacitinib Monotherapy
Tofacitinib
by NEXT STEPS IN DERM TEAM on
INTRODUCTION Tofacitinib is a Janus kinase (JAK) 1-3 inhibitor first U.S. Food and Drug Administration (FDA) approved in 2012 for rheumatoid arthritis, with subsequent approval for psoriatic arthritis, ulcerative colitis, polyarticular course juvenile idiopathic arthritis, and ankylosing spondylitis in 2017, 2018, 2020, and 2021, respectively.1,2 In the last several years, oral tofacitinib …

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Severe Psoriasis Presenting in 3-Year-Old Child With Nail Dystrophy: Response to Biologic Treatment
psoriasis
by NEXT STEPS IN DERM TEAM on
Psoriasis, a chronic inflammatory skin condition, affects about 2% of children. A small subset have isolated nail involvement refractory to topical treatment that can be disabling. The development of targeted biologic agents offers safe, effective options for children with moderate-to-severe skin and nail disease. A few are now Food and Drug Administration (FDA)-approved for children. INTRODUCTIO …

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Intralesional Methotrexate & 5-Fluorouracil for Keratoacanthomas | Cheat Sheet
keratoacanthomas
by Vishal A. Patel, MD | Michael J. Visconti, DO on
Keratoacanthomas are a low-grade, well-differentiated variant of squamous cell carcinoma. Characteristically, their abrupt-onset and crateriform microscopic findings assist with their differentiation from more aggressive squamous cell carcinoma. While surgical treatment remains a viable and appropriate option for their management, clinical scenarios (described below) may portend to better outcomes …

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The Many Faces of Psoriasis | Part 2
psoriasis
by Lauren C. Payne, MD, MS, FAAD on
Did you know that psoriasis doesn’t just present on the arms, legs, and trunk? It can also appear in non-conventional locations (aka “special site” psoriasis) including the scalp, face, and body folds (such as the axillary, inframammary, and inguinal fields, and intergluteal clefts). In the skin folds, psoriasis is also referred to as “inverse psoriasis.” In darker skin types, the areas …

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Tralokinumab-ldrm Therapeutic Cheat Sheet
tralokinumab
by Emily Murphy, MD on
Atopic dermatitis is a common, chronic, life-altering disease. With its visibility and debilitating pruritus, atopic dermatitis significantly impacts our patients’ quality of life. For those with resistant and extensive disease, we are happy to have numerous new systemic agents at our disposal, one being tralokinumab, an IL-13 antagonist. We continue our series, Therapeutic Cheat Sheet, with a c …

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