Utility of Pulsed-Dye Laser in the Treatment of Recalcitrant Hailey-Hailey Disease
INTRODUCTION
Benign Familial Pemphigus, or Hailey-Hailey Disease (HHD), affects intertriginous areas of the skin causing epidermal blistering and vesicles that coalesce into weeping and crusting plaques.¹
The loss-of-function mutation of the ATP2C1 gene causes a disruption in calcium homeostasis of keratinocytes. The resulting dysfunction in desmosomes and cell-cell adhesion causes acanthol …
INTRODUCTION
Benign Familial Pemphigus, or Hailey-Hailey Disease (HHD), affects intertriginous areas of the skin causing epidermal blistering and vesicles that coalesce into weeping and crusting plaques.¹
The loss-of-function mutation of the ATP2C1 gene causes a disruption in calcium homeostasis of keratinocytes. The resulting dysfunction in desmosomes and cell-cell adhesion causes acanthol … 
The November 2023 issue of the Journal of Drugs in Dermatology (JDD) focuses on lasers, light sources, and devices featuring the perfect mix original articles, case reports, letters to the editor, and brief communications. Straight from the Editor’s desk, check out this month’s issue highlights.
ORIGINAL ARTICLES
Interventions to Minimize Pain During Photodynamic Therapy With 5-Aminolevulini … 
INSIDER recently posted an article on oral minoxidil for hair loss as a result of media coverage in The New York Times. Which hair loss patients make good candidates for oral minoxidil? How should a dermatologist determine the best dosage for their patients?
For expert advice, I reached out to Shilpi Khetarpal, MD, FAAD, director of cosmetic dermatology and lasers at the Cleveland Clinic.
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2021 is the 50th anniversary of the FDA approval of minocycline (MCN). While many other antibiotics have become obsolete during this time, MCN continues to be quite useful. In dermatology, MCN is used prominently in acne vulgaris, and is also employed in many other dermatological conditions because of its molecular and pharmacological properties. In this article, we review the history of minocycli … 
Broad spectrum tetracyclines are a well-known, widely used, and often successful treatment for use in inflammatory skin pathologies such as acne and rosacea. However, the steady rise of antibiotic resistance and gut dysbiosis associated with broad spectrum tetracyclines emphasizes the importance and responsibility of antibiotic stewardship. Narrow spectrum antibiotics have become increasingly impo … 