Friday Pop Quiz 3/20/2026

What histologic features are typically seen on a skin biopsy of this lesion?

A. Necrobiotic degeneration of dermal collagen surrounded by an inflammatory reaction

B. Layers with open-ended necrobiotic foci; lack of mucin; increased numbers of plasma cells (necrobiosis lipoidica)

C. Larger areas of eosinophilic necrobiosis and a lack of mucin deposition (rheumatoid nodule)

D. Immunohistochemistry revealing cytokeratin and epithelial membrane antigen (EMA) positivity (epithelioid sarcoma)

E. Eosinophilic areas of necrosis and an atypical infiltrate on closer inspection (epithelioid sarcoma)

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