A 6-month old infant develops tense blisters on the distal extremities which develop on normal-appearing skin. He has a neurologic disease and has been immobilized for a long period of time. The blisters spontaneously heal within 1-2 weeks. You suspect a diagnosis of coma bullae. Which of the following is the key characteristic histologic feature that would assist you in making this diagnosis?
A. Necrosis of sweat glands
B. Intraepidermal bullae
C. Subepidermal bullae
D. Pronounced inflammatory cell infiltrate
E. Positive direct immunofluorescence for IgG and C3
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