Next Steps in Derm and the Journal of Drugs in Dermatology, in partnership with the Dermatology Education Foundation (DEF) and Physicians Resources, interviewed Dr. Adam Friedman, professor and chair of dermatology at GW School of Medicine and Health Sciences, on life lessons from his residency and career. Dr. Friedman provides his tips for remaining calm during the craziest of office visits. He also shares why being fun, creative and an off-label bandit matters. Want to know Dr. Friedman’s secret sauce for enjoying work? Watch this video for encouragement on how to thrive in the challenges of a dermatology clinic.
Dr. Adam Friedman lectured on this and other topics at the recent DERM2022 NP/PA CME conference held July 28-31, 2022.
If you want to read more about off-label uses in dermatology, check out the following articles published in the Journal of Drugs in Dermatology:
Off-Label Uses of JAK Inhibitors in Dermatology
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is a crucial component of immune function, and JAK inhibitors allow dermatologists to regulate this pathway in certain disease states. Once bound to ligands, JAKs phosphorylate cytokine receptors and STAT proteins, which translocate to the nucleus and activate transcription of immunologic proteins.1 Four JAK isoforms have been identified: JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2). The different isoforms bind varyingly to cytokines including interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21. While the first-generation JAK inhibitors — tofacitinib, ruxolitinib, and baricitinib — block multiple JAK isoforms, second generation JAK inhibitors, such as decernotinib, abrocitinib, and upadacitinib, target a particular JAK, reducing adverse effects.
Offering an Off-Label Therapeutic Algorithm for Lichen Planus
Lichen planus (LP) is a poorly characterized, chronic inflammatory dermatosis notable for violaceous to brown/ black polygonal pruritic papules and plaques, often with lacey scale, and reticular white erosions involving mucosal sites.
Tox Outside the Box: Off-Label Aesthetic Uses of Botulinum Toxin
Proceedings from a cosmetic dermatology conference, Cosmetic Bootcamp, Aspen, CO
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