It’s Mnemonic Monday! Extramammary Paget’s Disease
On this Mnemonic Monday, we challenge you to remember immunohistochemical markers for paget cells in Extramammary Paget’s Disease with the following mnemonic:
"EXTRA GROSS LOVE PASSES CANCER"
Extra- Extramammary Paget’s Disease
Gross- Gross cystic disease fluid protein 15 (GCDFP-15)
LOVE- Low molecular weight cytokeratins
PASses- Period acid-Schiff (PAS)
CANCER- CEA
The wo …
On this Mnemonic Monday, we challenge you to remember immunohistochemical markers for paget cells in Extramammary Paget’s Disease with the following mnemonic:
"EXTRA GROSS LOVE PASSES CANCER"
Extra- Extramammary Paget’s Disease
Gross- Gross cystic disease fluid protein 15 (GCDFP-15)
LOVE- Low molecular weight cytokeratins
PASses- Period acid-Schiff (PAS)
CANCER- CEA
The wo … Continue reading "It’s Mnemonic Monday! Extramammary Paget’s Disease"
A 6-month old infant develops tense blisters on the distal extremities which develop on normal-appearing skin. He has a neurologic disease and has been immobilized for a long period of time. The blisters spontaneously heal within 1-2 weeks. You suspect a diagnosis of coma bullae. Which of the following is the key characteristic histologic feature that would assist you in making this diagnosis? … 
A 65-year-old female patient presents with poorly demarcated, symmetric, very painful patches of erythema and retiform purpura, favoring the thighs and buttocks. Bullae and a dusky gray discoloration developed, as well as the appearance of ulcerations with black, leathery eschars. A skin biopsy of the affected area is suggestive of calciphylaxis. Shortly after, she dies from secondary infectio … 
This tumor commonly results from mutations in p53. Which of the following is correct?
A. It is the most common type of skin cancer in Caucasians
B. Oral variants most commonly present on the dorsal tongue
C. It is typically less aggressive in patients with CLL
D. plant patients have a 10-fold increased risk of developing this tumor
E. Tumors arising within scars/chronic ulcers h … 
A biopsy for DIF is negative. IIF is positive for IgG antibodies directed against monkey esophagus. Which of the following is true regarding the diagnosis?
A. The primary target antigen is desmoglein 1
B. A positive DIF would show intercellular and linear IgG & C3 along the BMZ
C. It is associated with bronchiolitis obliterans
D. Autoantibody titers correlate with disease activ … 