Friday Pop Quiz #401

The correct answer is A: autosomal dominant

This patient has Hailey-Hailey disease, also knows as benign familial pemphigus. It is a genodermatosis that is inherited in an autosomal dominant pattern.

Hailey Hailey disease is inherited in an autosomal dominant pattern, and thus choices B and C are incorrect. While there are cases of Hailey-Hailey disease caused from sporadic mutations reported without a family history, this is less common than the typical inheritance pattern of autosomal dominant.

References: Porro AM, Arai Seque C, Miyamoto D, Vanderlei Medeiros da Nóbrega D, Simões E Silva Enokihara MM, Giuli Santi C. Hailey-Hailey disease: clinical, diagnostic and therapeutic update. An Bras Dermatol. 2024;99(5):651-661. doi:10.1016/j.abd.2023.12.003

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