Friday Pop Quiz #396

The correct answer is A. Ferguson-Smith, AD.

This patient is presenting with the Ferguson-Smith variant of inherited keratoacanthoma syndromes. This is autosomal dominant, usually presents in the 3rd decade of life, and presents as rapid KA onset and spontaneous resolution without scaring.

The Grzbowski variant is sporadic and presents with 1000’s of milia like KA’s later in life. This variant is associated with scarring and ectropion and may involve the airway.

References: Litaiem N, Khammouma F, Mrad M, Bacha T, Belhadj Kacem L, Zeglaoui F. Multiple keratoacanthomas of Ferguson-Smith type. Clin Case Rep. 2022 Oct 11;10(10):e06429. doi: 10.1002/ccr3.6429. PMID: 36245454; PMCID: PMC9552544.