A 65-year-old male patient with a history of chronic sun exposure presents with the lesion pictured that has developed over the past year. The histopathological findings are notable for enlarged keratinocytes infiltrating into the dermis. What type of mutation is most commonly seen in the pathogenesis of this tumor?

A. Transition

B. Transversion

C. Termination

D. Pyrimidine dimer

E. 8-oxoGuanine

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