Friday Pop Quiz 10/2/2026
A 26-year-old man with a history of cystic fibrosis initiated a new cystic fibrosis medication two months ago. Approximately one week ago, the patient noticed the abrupt onset of papules on his upper back, as shown, for which he has tried using a benzoyl peroxide wash without improvement. Which of the following is the most appropriate next step?
A. Cessation of cystic fibrosis medication
…
A 26-year-old man with a history of cystic fibrosis initiated a new cystic fibrosis medication two months ago. Approximately one week ago, the patient noticed the abrupt onset of papules on his upper back, as shown, for which he has tried using a benzoyl peroxide wash without improvement. Which of the following is the most appropriate next step?
A. Cessation of cystic fibrosis medication
… 
What immunohistochemical stain is most likely to be positive in this condition?
A. HPV
B. HHV-8
C. PAS
D. S100
E. CD207
To find out the correct answer and read the explanation, click here.
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A previously healthy 55-year-old patient presents with a four-month history of the pictured indurated papules and plaques. History does not reveal prior skin problems. The lesions started on the cheeks and are now affecting the forehead. The sun seems to exacerbate the condition, causing mild burning and pruritus. Patient complains of cheek swelling that worsens in the morning and improves as … 
A 7-year-old boy presents with recurrent crops of pink papules on the trunk, buttocks, and proximal extremities, as shown in the clinical image. The lesions ulcerate and heal with varioliform scarring. Which of the following histologic findings would not be expected in this condition?
A. Lichenoid infiltrate
B. Extravasation of red blood cells
C. Dyskeratosis
D. Parakeratosis
E. … 
A 45-year-old man presents to the office with weakness and the lesions on his hand pictured. His symptoms have been progressively worsening over the last 5 months. He works as a nurse and has had difficulty walking up the stairs and lifting patients. He has a history of frontal migraines for which he occasionally takes ibuprofen. He takes a cholesterol lowering medication and is otherwise heal …