Topical PDT Photosensitizers (5-ALA and MAL) Therapeutic Cheat Sheet
5-aminolevulinic acid (5-ALA) is an FDA-approved prodrug used in combination with light therapy for treatment of actinic keratosis and superficial basal cell carcinoma. It is a naturally occurring amino acid that is an intermediate of the heme biosynthesis pathway which cells convert into the photosensitizing metabolite protoporphyrin IX (PpIX). This compound has been applicable in two specific cl …
5-aminolevulinic acid (5-ALA) is an FDA-approved prodrug used in combination with light therapy for treatment of actinic keratosis and superficial basal cell carcinoma. It is a naturally occurring amino acid that is an intermediate of the heme biosynthesis pathway which cells convert into the photosensitizing metabolite protoporphyrin IX (PpIX). This compound has been applicable in two specific cl … Continue reading "Topical PDT Photosensitizers (5-ALA and MAL) Therapeutic Cheat Sheet"
Photodynamic therapy (PDT) involves a lot of choices for a clinician, from deciding how to prepare the skin for a photosensitizer to selecting the light source. Next Steps in Derm, in partnership with the ODAC Dermatology Conference, addresses proven strategies for PDT in this interview with ODAC Conference Co-Chair Vishal A. Patel, MD, FACMS. Watch as Dr. Patel outlines varied options for enhanci …