Friday Pop Quiz 10/30/2026
A 20 year old female patient presents with the following painful, eroded and crusted rash in her axillae. She reports she has family members with a similar diagnosis. What is the mode of inheritance of this condition?
A. Autosomal dominant
B. Autosomal recessive
C. X-linked dominant
D. X-linked recessive
E. It is not a genetic disorder
To find out the correct answer and read th …
A 20 year old female patient presents with the following painful, eroded and crusted rash in her axillae. She reports she has family members with a similar diagnosis. What is the mode of inheritance of this condition?
A. Autosomal dominant
B. Autosomal recessive
C. X-linked dominant
D. X-linked recessive
E. It is not a genetic disorder
To find out the correct answer and read th … 
Introduction
Benign Familial Pemphigus (Hailey-Hailey Disease [HHD]) is caused by a mutation within ATP2C1, the gene encoding the calcium pump of golgi apparatuses, impacting keratinocytes' ability to adhere to each other, resulting in acantholysis.1 Clinical presentation of HHD encompasses blisters that become erythematous plaques and fissures within flexural areas on a relapsing basis … 
INTRODUCTION
Benign Familial Pemphigus, or Hailey-Hailey Disease (HHD), affects intertriginous areas of the skin causing epidermal blistering and vesicles that coalesce into weeping and crusting plaques.¹
The loss-of-function mutation of the ATP2C1 gene causes a disruption in calcium homeostasis of keratinocytes. The resulting dysfunction in desmosomes and cell-cell adhesion causes acanthol … 
Did you know that psoriasis doesn’t just present on the arms, legs, and trunk? It can also appear in non-conventional locations (aka “special site” psoriasis) including the scalp, face, and body folds (such as the axillary, inframammary, and inguinal fields, and intergluteal clefts). In the skin folds, psoriasis is also referred to as “inverse psoriasis.” In darker skin types, the areas …