Prurigo Nodularis and Chronic Itch: What’s the Connection?
Intense itch is a common feature of prurigo nodularis. Why is this the case? Next Steps in Derm, in partnership with Skin of Color Update, interviewed Dr. Raj J. Chovatiya, associate professor at Rosalind Franklin University of Medicine and Science Chicago Medical School. Dr. Chovatiya, who has a PhD in immunology, outlines the science behind the “unbreakable loop” of chronic itch in prurigo …
Intense itch is a common feature of prurigo nodularis. Why is this the case? Next Steps in Derm, in partnership with Skin of Color Update, interviewed Dr. Raj J. Chovatiya, associate professor at Rosalind Franklin University of Medicine and Science Chicago Medical School. Dr. Chovatiya, who has a PhD in immunology, outlines the science behind the “unbreakable loop” of chronic itch in prurigo … Continue reading "Prurigo Nodularis and Chronic Itch: What’s the Connection?"
Lebrikizumab is a humanized immunoglobulin G4 (IgG4) monoclonal antibody that selectively targets IL-13, a key cytokine implicated in the pathogenesis of type 2 inflammatory diseases.1 Lebrikizumab binds IL-13 with high affinity and a slow dissociation rate, which prevents heterodimerization of the IL-13 receptor alpha-1 subunit (IL-13Rα1) with the IL-4 receptor alpha (IL-4Rα) signaling complex. … 
Prurigo nodularis (PN) is far more than just a persistent itch—it is a distinct, neuroimmune-driven disease entity that demands its own targeted diagnostic and therapeutic roadmap. During a standout session at this year's Skin of Color Update in New York City, Dr. Raj Chovatiya challenged the long-held notion that PN is merely a variant of atopic dermatitis. For patients with skin of color, wher … 
Atopic dermatitis and prurigo nodularis are chronic, life-altering diseases with a common feature of debilitating pruritus that significantly impacts our patients’ qualities of life. For those with resistant and extensive disease, dermatologists now have nemolizumab in our armamentarium, the first FDA approved IL-31 inhibitor. We continue our series, Therapeutic Cheat Sheet, with a closer look a … 
As dermatologists, we recognize that chronic itch is a complex and often debilitating condition that significantly impacts our patients' quality of life, affecting their physical health, mental well-being, and daily activities. Chronic itch can be especially challenging to diagnose and treat, particularly in patients with skin of color, who may experience unique clinical manifestations and complic …